2001 The FEBS journal
CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK)
Gen Yosimichi, Tohru Nakanishi, Takashi Nishida, Takako Hattori TerukoTakano-Yamamoto, Masaharu Takigawa
2002 Biochemical and Biophysical Research Communications
CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes
Gen Yosimichi, Satoshi Kubota, Takako Hattori, Takashi Nishida, Kumiko Nawachi, Tohru Nakanishi, Masafumi Kamada , Teruko Takano-Yamamoto, Masaharu Takigawa
2002 Journal of Celluar Physiorogy
CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes
Takashi Nishida, Satoshi Kubota, Tohru Nakanishi, Takuo Kuboki, Gen Yosimichi, Seiji Kondo, Masaharu Takigawa
2002 Cacinogenesis
Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases
Seiji Kondo, Satoshi Kubota, Tsuyoshi Shimo, Takashi Nishida, Gen Yosimichi, Takanori Eguchi, Toshio Sugahara and Masaharu Takigawa
2002 FEBS Letters
Tyrosine kinase-type receptor ErbB4 in chondrocytes: interaction with connective tissue growth factor and distribution in cartilage
Kumiko Nawachi, Miho Inoue, Satoshi Kubota, Takashi Nishida, Gen Yosimich, Tohru Nakanish, Manabu Kanyama, Takuo Kuboki, Hirofumi Yatani, Tomoichiro Yamaai, Masaharu Takigawa
2003 Journal of Celluar Physiorogy
CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes
Takashi Nishida, Satoshi Kubota, Tomohiro Fukunaga Seiji Kondo, Gen Yosimichi, Tohru Nakanishi, Teruko Takano-Yamamoto, Masaharu Takigawa
2005 Cell communication and Signaling
Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells
Masahiro Asano, Satoshi Kubota Tohru Nakanishi, Takashi Nishida Tomoichiro Yamaai, Gen Yosimichi Kazumi Ohyama, Tomosada Sugimoto, Yoji Murayama, and Masaharu Takigawa
2006 Bone
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes
Gen Yosimichi, Satoshi Kubota, Takashi Nishida, Seiji Kondo, Takeshi Yanagita, Kyouji Nakao, Teruko Takano-Yamamoto, Masaharu Takigawa
2006 Molecular Cancer Therapeutics
Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells
Seiji Kondo, Noriko Tanaka, Satoshi Kubota, Yoshiki Mukudai, Gen Yosimichi, Toshio Sugahara and Masaharu Takigawa
2006 Biochimie
Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in culture
S. Kubota, H. Kawaki S. Kondo, G. Yosimichi, M. Minato, T. Nishida, H. Hanagata, A. Miyauchi, M. Takigawa